Birth defects are one of the leading causes of neonatal mortality worldwide. Every year more than 8.14 million children are born with a serious birth defect. The risk factors predictive of birth defects in babies vary from country to country even from region to region. About 60% of the causes of birth defect in humans are still unknown. However, in about 25% cases, the causes seem to be “multifactorial”, indicating a complex interaction between genetic and environmental risk factors. Many studies have been conducted to determine the association of various risk factors with the incidence of birth defects.